Characterization of cellular uptake and toxicity of aminosilane-coated iron oxide nanoparticles with different charges in central nervous system-relevant cell culture models.
Identifieur interne : 000E30 ( Main/Exploration ); précédent : 000E29; suivant : 000E31Characterization of cellular uptake and toxicity of aminosilane-coated iron oxide nanoparticles with different charges in central nervous system-relevant cell culture models.
Auteurs : Zhizhi Sun [Canada] ; Vinith Yathindranath ; Matthew Worden ; James A. Thliveris ; Stephanie Chu ; Fiona E. Parkinson ; Torsten Hegmann ; Donald W. MillerSource :
- International journal of nanomedicine [ 1178-2013 ] ; 2013.
English descriptors
- KwdEn :
- Analysis of Variance, Animals, Astrocytes (drug effects), Astrocytes (metabolism), Cell Line, Cell Survival (drug effects), Drug Carriers (chemistry), Drug Carriers (pharmacokinetics), Drug Carriers (pharmacology), Magnetite Nanoparticles (administration & dosage), Magnetite Nanoparticles (chemistry), Mice, Neurons (drug effects), Neurons (metabolism), Silanes (chemistry), Silanes (pharmacokinetics), Silanes (pharmacology).
- MESH :
- chemical , administration & dosage : Magnetite Nanoparticles.
- chemical , chemistry : Drug Carriers, Magnetite Nanoparticles, Silanes.
- drug effects : Astrocytes, Cell Survival, Neurons.
- metabolism : Astrocytes, Neurons.
- chemical , pharmacokinetics : Drug Carriers, Silanes.
- chemical , pharmacology : Drug Carriers, Silanes.
- Analysis of Variance, Animals, Cell Line, Mice.
Abstract
Aminosilane-coated iron oxide nanoparticles (AmS-IONPs) have been widely used in constructing complex and multifunctional drug delivery systems. However, the biocompatibility and uptake characteristics of AmS-IONPs in central nervous system (CNS)-relevant cells are unknown. The purpose of this study was to determine the effect of surface charge and magnetic field on toxicity and uptake of AmS-IONPs in CNS-relevant cell types.
DOI: 10.2147/IJN.S39048
PubMed: 23494517
Affiliations:
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Le document en format XML
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Thliveris</name></author><author><name sortKey="Chu, Stephanie" sort="Chu, Stephanie" uniqKey="Chu S" first="Stephanie" last="Chu">Stephanie Chu</name></author><author><name sortKey="Parkinson, Fiona E" sort="Parkinson, Fiona E" uniqKey="Parkinson F" first="Fiona E" last="Parkinson">Fiona E. Parkinson</name></author><author><name sortKey="Hegmann, Torsten" sort="Hegmann, Torsten" uniqKey="Hegmann T" first="Torsten" last="Hegmann">Torsten Hegmann</name></author><author><name sortKey="Miller, Donald W" sort="Miller, Donald W" uniqKey="Miller D" first="Donald W" last="Miller">Donald W. Miller</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23494517</idno><idno type="pmid">23494517</idno><idno type="doi">10.2147/IJN.S39048</idno><idno type="wicri:Area/PubMed/Corpus">000979</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000979</idno><idno type="wicri:Area/PubMed/Curation">000979</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000979</idno><idno type="wicri:Area/PubMed/Checkpoint">000979</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000979</idno><idno type="wicri:Area/Ncbi/Merge">001405</idno><idno type="wicri:Area/Ncbi/Curation">001405</idno><idno type="wicri:Area/Ncbi/Checkpoint">001405</idno><idno type="wicri:Area/Main/Merge">000E42</idno><idno type="wicri:Area/Main/Curation">000E30</idno><idno type="wicri:Area/Main/Exploration">000E30</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Characterization of cellular uptake and toxicity of aminosilane-coated iron oxide nanoparticles with different charges in central nervous system-relevant cell culture models.</title><author><name sortKey="Sun, Zhizhi" sort="Sun, Zhizhi" uniqKey="Sun Z" first="Zhizhi" last="Sun">Zhizhi Sun</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Yathindranath, Vinith" sort="Yathindranath, Vinith" uniqKey="Yathindranath V" first="Vinith" last="Yathindranath">Vinith Yathindranath</name></author><author><name sortKey="Worden, Matthew" sort="Worden, Matthew" uniqKey="Worden M" first="Matthew" last="Worden">Matthew Worden</name></author><author><name sortKey="Thliveris, James A" sort="Thliveris, James A" uniqKey="Thliveris J" first="James A" last="Thliveris">James A. Thliveris</name></author><author><name sortKey="Chu, Stephanie" sort="Chu, Stephanie" uniqKey="Chu S" first="Stephanie" last="Chu">Stephanie Chu</name></author><author><name sortKey="Parkinson, Fiona E" sort="Parkinson, Fiona E" uniqKey="Parkinson F" first="Fiona E" last="Parkinson">Fiona E. Parkinson</name></author><author><name sortKey="Hegmann, Torsten" sort="Hegmann, Torsten" uniqKey="Hegmann T" first="Torsten" last="Hegmann">Torsten Hegmann</name></author><author><name sortKey="Miller, Donald W" sort="Miller, Donald W" uniqKey="Miller D" first="Donald W" last="Miller">Donald W. Miller</name></author></analytic><series><title level="j">International journal of nanomedicine</title><idno type="eISSN">1178-2013</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term><term>Animals</term><term>Astrocytes (drug effects)</term><term>Astrocytes (metabolism)</term><term>Cell Line</term><term>Cell Survival (drug effects)</term><term>Drug Carriers (chemistry)</term><term>Drug Carriers (pharmacokinetics)</term><term>Drug Carriers (pharmacology)</term><term>Magnetite Nanoparticles (administration & dosage)</term><term>Magnetite Nanoparticles (chemistry)</term><term>Mice</term><term>Neurons (drug effects)</term><term>Neurons (metabolism)</term><term>Silanes (chemistry)</term><term>Silanes (pharmacokinetics)</term><term>Silanes (pharmacology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Magnetite Nanoparticles</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Drug Carriers</term><term>Magnetite Nanoparticles</term><term>Silanes</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Astrocytes</term><term>Cell Survival</term><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Astrocytes</term><term>Neurons</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Drug Carriers</term><term>Silanes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Drug Carriers</term><term>Silanes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Animals</term><term>Cell Line</term><term>Mice</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aminosilane-coated iron oxide nanoparticles (AmS-IONPs) have been widely used in constructing complex and multifunctional drug delivery systems. However, the biocompatibility and uptake characteristics of AmS-IONPs in central nervous system (CNS)-relevant cells are unknown. The purpose of this study was to determine the effect of surface charge and magnetic field on toxicity and uptake of AmS-IONPs in CNS-relevant cell types.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Manitoba</li></region><settlement><li>Winnipeg</li></settlement><orgName><li>Université du Manitoba</li></orgName></list><tree><noCountry><name sortKey="Chu, Stephanie" sort="Chu, Stephanie" uniqKey="Chu S" first="Stephanie" last="Chu">Stephanie Chu</name><name sortKey="Hegmann, Torsten" sort="Hegmann, Torsten" uniqKey="Hegmann T" first="Torsten" last="Hegmann">Torsten Hegmann</name><name sortKey="Miller, Donald W" sort="Miller, Donald W" uniqKey="Miller D" first="Donald W" last="Miller">Donald W. Miller</name><name sortKey="Parkinson, Fiona E" sort="Parkinson, Fiona E" uniqKey="Parkinson F" first="Fiona E" last="Parkinson">Fiona E. Parkinson</name><name sortKey="Thliveris, James A" sort="Thliveris, James A" uniqKey="Thliveris J" first="James A" last="Thliveris">James A. Thliveris</name><name sortKey="Worden, Matthew" sort="Worden, Matthew" uniqKey="Worden M" first="Matthew" last="Worden">Matthew Worden</name><name sortKey="Yathindranath, Vinith" sort="Yathindranath, Vinith" uniqKey="Yathindranath V" first="Vinith" last="Yathindranath">Vinith Yathindranath</name></noCountry><country name="Canada"><region name="Manitoba"><name sortKey="Sun, Zhizhi" sort="Sun, Zhizhi" uniqKey="Sun Z" first="Zhizhi" last="Sun">Zhizhi Sun</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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